CLINICAL-DIAGNOSIS OF FRONTAL-LOBE DEMENTIA AND ALZHEIMERS-DISEASE - RELATION TO CEREBRAL PERFUSION, BRAIN ATROPHY AND ELECTROENCEPHALOGRAPHY

The regional cerebral blood flow, brain atrophy, white matter changes and neurophysiologic changes were evaluated in 28 patients with a clin ical diagnosis of probable Alzheimer's disease (AD) and in 8 patients with a clinical diagnosis of frontal lobe dementia (FLD) using single photon emission computed tomography, magnetic resonance imaging and el ectroencephalography (EEG). We found that FLD patients had more severe frontal blood flow reduction and less severe parietal blood flow redu ction compared to AD patients. Among patients with mild dementia the E EG changes were less severe in the FLD group. No significant differenc es were found in white matter changes or in regional atrophy.