QUANTITATIVE EEG MAPPING, REGIONAL CEREBRAL BLOOD-FLOW, AND NEUROPSYCHOLOGICAL FUNCTION IN ALZHEIMERS-DISEASE

The relations between quantitative EEG, regional cerebral blood flow ( rCBF), severity of disease and neuropsychological data were analyzed i n 31 patients in different stages of Alzheimer's disease (AD). As a gr oup the demented patients had higher delta and theta activities, lower alpha activity and lower alpha peak frequency than control subjects. rCBF was reduced in all regions studied but mainly in the temporoparie tal areas. An analysis of correlations showed a close relationship bet ween rCBF and certain quantitative EEG parameters in AD patients, main ly the power of the theta and delta bands. Both rCBF evaluation and qu antitative EEG provide functional information related to the severity of cognitive impairment.