LARGE-SCALE PREPARATION OF (2S,3S)-N-BOC-3-AMINO-1,2-EPOXY-4-PHENYLBUTANE - A KEY BUILDING-BLOCK FOR HIV-PROTEASE INHIBITORS

Authors
BEAULIEU PL WERNIC D DUCEPPE JS GUINDON Y
Citation
Pl. Beaulieu et al., LARGE-SCALE PREPARATION OF (2S,3S)-N-BOC-3-AMINO-1,2-EPOXY-4-PHENYLBUTANE - A KEY BUILDING-BLOCK FOR HIV-PROTEASE INHIBITORS, Tetrahedron letters, 36(19), 1995, pp. 3317-3320
Citations number
25
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
19
Year of publication
1995
Pages
3317 - 3320
Database
ISI
SICI code
0040-4039(1995)36:19<3317:LPO(>2.0.ZU;2-H
Abstract
(2S,3S)-N-Boc-3-amino-1,2-epoxy-4-phenylbutane is prepared in four ste ps from commercially available N,N-dibenzyl-L-phenylalaninol. The synt hesis is amenable to the preparation of kilogram quantities of enantio merically pure material.