FAMILIAL OCCURRENCE OF PATENT DUCTUS-ARTERIOSUS

We describe 7 relatives with patent ductus arteriosus (PDA) and a slig htly unusual facial appearance with prominent midface with nose elonga tion and flattening of the nasal bridge, wide-set eyes, downturned pal pebral fissures, mild ptosis, thickened lips, and apparently slightly low-set ears, Autosomal dominant inheritance is suggested in this fami ly, Other families where affected members have PDA and a similar facia l appearance and autosomal dominant inheritance were described previou sly by Char [1978: BD:OAS XIV (6B):303-305] and Temple [1992: Clin Dys morphol 1:17-21]. (C) 1995 Wiley-Liss, Inc.