PI-STACKING EFFECTS IN ASYMMETRIC-SYNTHESIS

The effects and benefits of pi stacking in asymmetric synthesis is rev iewed. Specifically, asymmetric induction achieved with chiral auxilia ries and chiral catalysts can be enhanced by pi stacking effects, lock ing one conformation of a reactant preferentially in a given transitio n state assembly. The evolution of such systems, their application in synthesis, together with related developments in the held of molecular recognition will be highlighted.