A CONVENIENT ACCESS TO CHIRAL MONOFUNCTIONALIZED BICYCLIC GUANIDINIUMRECEPTOR GROUPS

An easy and high-yield route for the preparation of functional and chi ral hexahydropyrimido[1,2-a]pyrimidines 3 is described. Starting from known methioninol and 2-methylmercaptotetrahydropyrimidine 5, the targ et compounds, which may be useful as building blocks in the synthesis of polymodular molecular hosts, were obtained in over 50 % total yield . As an example the iodo compound 20 was converted into the homoargini ne analog 22 in 70 % yield.