ANTITUBULIN IMMUNOHISTOCHEMISTRY STUDY OF ECHINOCOCCUS-GRANULOSUS PROTOSCOLICES INCUBATED WITH ALBENDAZOLE AND ALBENDAZOLE SULFOXIDE IN-VITRO

Tubulin content was immunohistochemically studied in Echinococcus gran ulosus protoscolices incubated with albendazole and albendazole sulpho xide alone or in combination. Tubulin immunoreactivity was very patent in the control protoscolices and was mainly located in the sucker reg ion and the invagination channel of protoscolices. Treated protoscolic es always showed less immunoreactivity than did control protoscolices. We concluded that albendazole and its metabolite albendazole sulphoxi de produce tubulin alterations in E. granulosus protoscolices.