HETEROGENEITY OF GABA(A)-RECEPTORS - CELL-SPECIFIC EXPRESSION, PHARMACOLOGY, AND REGULATION

Authors
MOHLER H KNOFLACH F PAYSAN J MOTEJLEK K BENKE D LUSCHER B FRITSCHY JM
Citation
H. Mohler et al., HETEROGENEITY OF GABA(A)-RECEPTORS - CELL-SPECIFIC EXPRESSION, PHARMACOLOGY, AND REGULATION, Neurochemical research, 20(5), 1995, pp. 631-636
Citations number
40
Categorie Soggetti
Biology,Neurosciences
Journal title
Neurochemical research → ACNP
ISSN journal
03643190
Volume
20
Issue
5
Year of publication
1995
Pages
631 - 636
Database
ISI
SICI code
0364-3190(1995)20:5<631:HOG-CE>2.0.ZU;2-P
Abstract
Vigilance, anxiety, memory, epileptogenic activity and muscle tension can be regulated by a modulation of GABA(A)-receptor function. A multi tude of different GABA(A)-receptors exist in the brain due to the comb inatorial assembly Of various subunits encoded by at least 15 genes. T he clarification of the physiological and pharmacological significance of GABA(A)-receptor subtypes, in combination with their cellular loca lization, will make it possible to identify the neuronal circuits regu lating the respective CNS states and to provide strategies for the dev elopment of subtype-specific drugs for selective therapies.