A NEW DIFFERENTIATION FACTOR FROM HL-60 C ELL-CULTURE TREATED WITH RETINOIC ACID - ISOLATION AND SEQUENCING

Authors
KOSTANYAN IA ASTAPOVA MV STAROVOITOVA EV DRANITSYNA SM LIPKIN VM
Citation
Ia. Kostanyan et al., A NEW DIFFERENTIATION FACTOR FROM HL-60 C ELL-CULTURE TREATED WITH RETINOIC ACID - ISOLATION AND SEQUENCING, Bioorganiceskaa himia, 21(4), 1995, pp. 243-248
Citations number
29
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Bioorganiceskaa himia → ACNP
ISSN journal
01323423
Volume
21
Issue
4
Year of publication
1995
Pages
243 - 248
Database
ISI
SICI code
0132-3423(1995)21:4<243:ANDFFH>2.0.ZU;2-7
Abstract
A new 8.2-kDa protein factor was isolated from cell culture of a promy elocyte leukemic HL-60 cell line that exhibited a differentiation-indu cing effect upon the initial cell line. The primary structure of this factor was determined by sequencing the protein (N-terminal region) an d the corresponding cDNA. A molecule of the differentiation factor sec reted by HL-60 cells consisted of 54 amino acid residues and was glyco silated.