The impact of HIV infection on the health of American children is incr
easing, and minority children in certain urban areas are disproportion
ately affected. Because almost 90% of cumulative pediatric AIDS cases
and virtually all new pediatric HIV infections are attributable to per
inatal transmission, the HIV/AIDS epidemic in children reflects that i
n women of childbearing age. A promising new intervention to reduce pe
rinatal HIV infection is now available, but how the intervention will
be translated into routine clinical practice is still uncertain. To ma
ximize the public health impact of prevention strategies, implementati
on of the recommended interventions should be combined with early iden
tification of HN infection among women of childbearing age.