A NOVEL AND PRACTICAL METHOD FOR THE N-BROMOMETHYLATION OF IMIDES ANDISOTHIAZOLONE 1,1-DIOXIDES

Authors
COURT JJ LESSEN TA HLASTA DJ
Citation
Jj. Court et al., A NOVEL AND PRACTICAL METHOD FOR THE N-BROMOMETHYLATION OF IMIDES ANDISOTHIAZOLONE 1,1-DIOXIDES, Synlett, (5), 1995, pp. 423-424
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synlett → ACNP
ISSN journal
09365214
Issue
5
Year of publication
1995
Pages
423 - 424
Database
ISI
SICI code
0936-5214(1995):5<423:ANAPMF>2.0.ZU;2-P
Abstract
An efficient two-step procedure affords bromomethyl phenyl sulfide, N- bromomethyl-imides, and N-bromomethyl-isothiazolone 1,1-dioxides in hi gh yields. S- or N-Alkylation of the substrate 2 with chloromethyl piv alate (POMCl) gives the intermediate pivaloylmethyl derivatives 3 whic h on treatment with 5% HBr in acetic acid yields the bromomethyl deriv atives 4.