A PC-BASED GRAPHICAL SIMULATOR FOR PHYSIOLOGICAL PHARMACOKINETIC MODELS

Authors
WADA DR STANSKI DR EBLING WF
Citation
Dr. Wada et al., A PC-BASED GRAPHICAL SIMULATOR FOR PHYSIOLOGICAL PHARMACOKINETIC MODELS, Computer methods and programs in biomedicine, 46(3), 1995, pp. 245-255
Citations number
13
Categorie Soggetti
Mathematical Methods, Biology & Medicine","Computer Science Interdisciplinary Applications","Engineering, Biomedical","Computer Science Theory & Methods
Journal title
Computer methods and programs in biomedicine → ACNP
ISSN journal
01692607
Volume
46
Issue
3
Year of publication
1995
Pages
245 - 255
Database
ISI
SICI code
0169-2607(1995)46:3<245:APGSFP>2.0.ZU;2-D
Abstract
Since many intravenous anesthetic drugs alter blood flows, physiologic ally-based pharmacokinetic models describing drug disposition may be t ime-varying, Using the commercially available programming software MAT LAB, a platform to simulate time-varying physiological pharmacokinetic models was developed, The platform is based upon a library of pharmac okinetic blocks which mimic physiological structure. The blocks can be linked together flexibly to form models for different drugs, Because of MATLAB's additional numerical capabilities (e.g. non-linear optimiz ation), the platform provides a complete graphical microcomputer-based tool for physiologic pharmacokinetic modeling.