CAPSULAR TYPES AND ANTIBIOTIC SUSCEPTIBILITY OF PNEUMOCOCCI ISOLATED FROM PATIENTS IN BELGIUM WITH SERIOUS INFECTIONS, 1980-1993

During the 13-year period from 1 November 1980 to 31 January 1993, we received and serotyped a total of 5,619 clinically significant strains of Streptococcus pneumoniae isolated in more than 75 laboratories in Belgium (4,079 [72.6%] were from blood or pleural fluid, 462 [8.2%] we re from cerebrospinal fluid, 691 [12.3%] were from middle ear aspirate s, and 387 [6.8%] were from various other body fluids), The isolates b elonged to 64 of the 84 currently recognized serotypes. Among the 4,72 2 isolates tested for susceptibility since 1983, 22% were resistant to at least one antimicrobial agent. Resistance to penicillin has slowly increased since 1985 but remained stable at a level of 2%-4% between 1986 and 1993, Of the 119 isolates with reduced penicillin susceptibil ity, only 23 were fully resistant (MIG, greater than or equal to 2 mu g/mL) and none of these proved to be resistant to cephalosporins. Resi stance to erythromycin increased significantly from 5.2% in 1986 to 21 .5% in 1993. Resistance to penicillin and erythromycin was also more f requently recognized in a smaller number of capsular types of S. pneum oniae.