THE EFFECT OF INDOMETHACIN ON CYCLOSPORINE-A AND ITS SOLVENT-INDUCED INHIBITION OF ENDOTHELIUM-DEPENDENT RELAXATION AND THE DRUG-INDUCED CONTRACTION OF RABBIT ISOLATED ARTERIES

1. In the isolated rabbit arteries, the effects of intravenous cyclosp orin A preparation (Sandimmun) and its solvent (Cremophor-EL) on acety lcholine-induced endothelium-dependent relaxation were investigated in the absence and presence of indomethacin (10(-5) M), a cyclooxygenase inibitor. 2. The effect of indomethacin on the drug- and solvent-indu ced contraction of superior mesenteric artery was also evaluated. 3. T he inhibitory effects of cyclosporin and the solvent on endothelium-de pendent relaxations were decreased by indomethacin. The direct contrac tions produced by the drug and the solvent in rabbit mesenteric artery were inhibited by indomethacin.