THE EFFECT OF LONG-TERM ANTIBIOTIC-THERAPY UPON CILIARY BEAT FREQUENCY IN CHRONIC RHINOSINUSITIS

The mucociliary escalator is the first line of defence of the upper an d lower respiratory tracts (Greenstone and Cole, 1985; Sleigh et al., 1988). Failure of mucociliary clearance is associated with chronic or recurrent respiratory tract infection. Ten patients with chronic rhino sinusitis underwent nasal brushings for the assessment of ciliary beat Frequency. In two no beating cilia were seen; in the remainder the me an value was 9.3 Hz +/- 2.3; range 6.1-12.8 Hz (n = 8). Following thre e months continuous oral antibiotic therapy repeat nasal brushings dem onstrated increased ciliary beat frequencies in all patients, mean val ue 13.7 Hz +/- 1.6; range 11.5-16.3 Hz (n = 10); (p<0.01; paired t-tes t). Depression of mucociliary clearance can occur secondarily to chron ic infection and is improved by prolonged antibiotics.