SUSTAINED-RELEASE TABLET CONTAINING OXAZEPAM - STUDY AND DESIGN

Sustained-release tablets containing oxazepam were prepared and dissol ution profiles were investigated. The total dose of oxazepam is consti tuted of initial and maintenance dosage. A method for the preparation of hydrophilic matrix tablets is presented. The study of the dissoluti on rate of these preparations in artificial gastric (in the first two hours) and enteric juices (in the following ten hours) was experimente d. No significant differences in oxazepam release rate were found betw een the formulations containing lactose, zinc sulfate, calcium sulfate or calcium phosphate added intragranularly to the maintenance dosage. The dissolutions studies of oxazepam preparations demonstrated differ ences in drug release properties depending on the content of extragran ular croscarmellose sodium.