C. Mbalipemba et D. Chulia, LACTOSE TEXTURE MONITORING DURING COMPACTING .2. DETAILED TEXTURAL ANALYSIS IN PORE GROUPS, Drug development and industrial pharmacy, 21(5), 1995, pp. 623-631
Study of the texture of lactose compacts under various confinement pre
ssures (100, 300 and 600 bar) was carried out by pore group analysis.
Awareness of the groups of large pores, the number of which is reduced
in response to pressure to yield more, smaller pores which are theref
ore increased in number and the change in the pore profile in terms of
volume, diameter and length has made it possible to obtain a better u
nderstanding of the mechanisms of densification and cohesion acquisiti
on in terms of lactose type and compression parameters. The authors di
stinguish between: -substances which resist rearrangement and acquire
cohesion whilst maintaining a high degree of porosity, - substances wh
ich increase in density by rearrangement and then fragmentation which
is accompanied by a significant increase in cohesion, - substances the
structure of which collapses, by fragmentation, multiplying contact p
oints, but in which the energy cannot be converted to sufficient cohes
ion.