COLORIMETRIC DETERMINATION OF MEBEVERINE HYDROCHLORIDE IN TABLETS BY CHARGE-TRANSFER COMPLEXATION

Three simple, rapid and sensitive colorimetric methods for the assay o f mebeverine hydrochloride are described. The first method is based on the reaction of mebeverine with iodine to give a yellow molecular cha rge transfer complex in chloroform with a maximum absorbance at 292nm. The other two on the formation of radical anions between mebeverine a nd tetracyanoethylene (TONE) or 7,7,8,8-tetracyanoquinodimethane (TCNQ ) in acetonitrile with absorbance maxima at 416, 840 nm, respectively. Beer's law was obeyed for the proposed methods, the apparent molar ab sorptivities were calculated to be 1.42x10(5), 1.46x10(4) and 1.59x10( 4) respectively. The proposed methods have been applied for the assay of mebeverine hydrochloride in commercial tablets.