MODULATORY EFFECTS OF BIOGENIC-AMINES ON ADIPOKINETIC HORMONE-SECRETION FROM LOCUST CORPORA CARDIACA IN-VITRO

The control of the release of adipokinetic hormones from neurosecretor y cells within the glandular lobes of the corpus cardiacum involving a xons running through the paired nervus corporis cardiaci II is unclear . Cyclic-AMP (cAMP) is clearly a second messenger. The effects of four biogenic amines (octopamine, dopamine, tyramine, and serotonin) on th e release of adipokinetic hormone-I were investigated in vitro. None h ad an effect on its own; they all potentiated the hormone release indu ced by cAMP-activating agents. Dopamine and serotonin were only presen t in the neurohemal part of the corpus cardiacum. Octopamine and tyram ine were not detectable in the corpus cardiacum. (C) 1995 Academic Pre ss, Inc.