GLUCOSE DOES NOT REVERSE IMPAIRMENTS ON SPONTANEOUS-ALTERNATION INDUCED BY THE NONCOMPETITIVE NMDA ANTAGONIST MK-801

N-Methyl-D-aspartate (NMDA) antagonists have been demonstrated to impa ir acquisition in a variety of tasks, including maze learning. It was previously reported from this laboratory that glucose can reverse the deficits on spontaneous alternation resulting from administration of t he competitive NMDA antagonist NPC 12626 in mice. The present study te sted the ability of glucose to reverse deficits induced by the noncomp etitive NMDA antagonist MK-801. Although subcutaneous administration o f 0.10 mg/kg of MK-801 resulted in a deficit on spontaneous alternatio n, glucose (100 and 250 mg/kg) did not reverse the impairment. This di fference in the ability of glucose to reverse the impairment caused by the two NMDA antagonists may reflect their different modes of actions at the NMDA receptor complex. (C) 1995 Academic Press, Inc.