SATIETY EFFECTS OF THE TYPE-A CCK RECEPTOR ANTAGONIST LOXIGLUMIDE IN LEAN AND OBESE WOMEN

Several studies have demonstrated that administration of cholecystokin in (CCK) reduces food intake in several species, including humans. In animal studies CCK-receptor antagonists have been reported to increase food intake, suggesting a physiological satiety effect of CCK in thes e animals. In a double-blind, placebo-controlled study, we investigate d the effect of the specific CCK-A receptor antagonist loxiglumide on food intake (carbohydrate-rich meal) and on subjective hunger feelings scored with visual analogue scales and food selection lists in seven healthy obese women and in seven healthy lean women. Loxiglumide was a dministered intravenously in a dose of 10 mg/kg ideal weight/h. For th e whole group, food intake during loxiglumide (359 +/- 39 g) was not s ignificantly different from food intake during saline infusion (333 +/ - 31 g). Also, when the lean and obese subgroups were analyzed separat ely, no significant influence of loxiglumide on food intake was found. In addition, no significant differences in satiety scores were seen u sing the food selection lists or visual analogue scales. In conclusion , in the present study during infusing the CCK-A receptor antagonist l oxiglumide we found no increase in preprandial satiety nor in food int ake of a carbohydrate-rich meal nor in postprandial satiety in lean an d obese women.