ADULT-ONSET STILLS DISEASE WITH SUBMASSIVE HEPATIC-NECROSIS

We present a 74-year old woman who was hospitalized because of typical spiking fever, evanescent rash, polyarthralgia, lymphadenopathy, and marked elevation of serum transaminases and lactate dehydrogenase (LDH ) due to adult-onset Still's disease (AOSD) with submassive hepatic ne crosis. All of the symptoms and abnormal laboratory findings were dram atically improved after treatment with prednisolone. The clinical cour se of this patient indicates that AOSD with severe hepatic necrosis ca n successfully be treated with early administration of corticosteroid, although it remains unknown whether the disease can remain in remissi on with no or minimal treatment.