MULTICENTRIC LYMPHOMA INVOLVING LARGE GRANULAR LYMPHOCYTES IN A COW

This case report describes for the first time in the literature a bovi ne multicentric lymphoma involving large granular lymphocytes (LGL). C linically, the cow had typical manifestations of multicentric lymphoma with nonspecific signs. Most lymphocytes in cytological specimens fro m blood and lymph nodes had an LGL-morphology. Histopathologically mal ignant LGLs were found in the liver, kidneys, and lungs. The azurophil ic granules were clearly seen with May-Grunwald-Giemsa stain. The gran ules were slightly eosinophilic as shown with hematoxylineosin stain, and most stained intensively dark with phosphotungstic acid hematoxyli n.