CYCLODEXTRINS AND ENANTIOMERIC SEPARATIONS OF DRUGS BY LIQUID-CHROMATOGRAPHY AND CAPILLARY ELECTROPHORESIS - BASIC PRINCIPLES AND NEW DEVELOPMENTS

Investigation of individual drug enantiomers is required in pharmacoki netic and pharmacodynamic studies of drugs with a chiral centre. Cyclo dextrins (CDs) are extensively used in high-performance liquid chromat ography as stationary phases bonded to a solid support or as mobile ph ase additives in HPLC and capillary electrophoresis (CE) for the separ ation of chiral compounds. We describe here the basis for the liquid c hromatographic and capillary electrophoretic resolution of drug enanti omers and the factors affecting their enantiomeric separation. This re view covers the use of CDs and some of their derivatives in studies of compounds of pharmacological interest.