EFFECT OF GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR AND GRANULOCYTE-COLONY-STIMULATING FACTOR ON MELATONIN SECRETION IN RATS - IN-VIVO AND IN-VITRO STUDIES
K. Zylinska et al., EFFECT OF GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR AND GRANULOCYTE-COLONY-STIMULATING FACTOR ON MELATONIN SECRETION IN RATS - IN-VIVO AND IN-VITRO STUDIES, Journal of neuroimmunology, 56(2), 1995, pp. 187-190
The study was performed in order to clarify whether granulocyte-macrop
hage colony stimulating factor (GM-CSF) and granulocyte colony stimula
ting factor (G-CSF) affect melatonin production and release. We have f
ound that both factors (GM-CSF at doses of 10.0 and 100.0 mu g/kg, and
G-CSF at doses of 1.0, 10.0, and 100.0 mu g/kg) stimulate melatonin s
ecretion in rats in vivo. Positive correlations between tested doses o
f GM-CSF and G-CSF and plasma melatonin levels were observed (P < 0.01
). Moreover, GM-CSF at doses of 2.0 and 20.0 ng/ml activated in vitro
the pineal gland to melatonin release (P < 0.05) in a dose-dependent m
anner.