MYOINOSITOL 1,4,6-TRISPHOSPHOROTHIOATE AND MYOINOSITOL 1,3,4-TRISPHOSPHOROTHIOATE - NEW SYNTHETIC CA2-MOBILIZING PARTIAL AGONISTS AT THE INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR()

Authors
MILLS SJ RILEY AM MURPHY CT BULLOCK AJ WESTWICK J POTTER BVL
Citation
Sj. Mills et al., MYOINOSITOL 1,4,6-TRISPHOSPHOROTHIOATE AND MYOINOSITOL 1,3,4-TRISPHOSPHOROTHIOATE - NEW SYNTHETIC CA2-MOBILIZING PARTIAL AGONISTS AT THE INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR(), Bioorganic & medicinal chemistry letters, 5(3), 1995, pp. 203-208
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
3
Year of publication
1995
Pages
203 - 208
Database
ISI
SICI code
0960-894X(1995)5:3<203:M1AM1>2.0.ZU;2-V
Abstract
Syntheses of myo-inositol 1,4,6-trisphosphorothioate and 1,3,4-trispho sphorothioate from myo-inositol are described; these trisphosphorathio ates, derived from structure-activity considerations of myo-inositol 1 ,3,4,6-tetrakisphosphate, are low intrinsic activity partial agonists at the platelet Ins(1,4,5)P-3 receptor.