NOVEL, WATER-SOLUBLE PHOSPHATE DERIVATIVES OF 2'-ETHOXY CARBONYLPACLITAXEL AS POTENTIAL PRODRUGS OF PACLITAXEL - SYNTHESIS AND ANTITUMOR EVALUATION

Authors
UEDA Y MATISKELLA JD MIKKILINENI AB FARINA V KNIPE JO ROSE WC CASAZZA AM VYAS DM
Citation
Y. Ueda et al., NOVEL, WATER-SOLUBLE PHOSPHATE DERIVATIVES OF 2'-ETHOXY CARBONYLPACLITAXEL AS POTENTIAL PRODRUGS OF PACLITAXEL - SYNTHESIS AND ANTITUMOR EVALUATION, Bioorganic & medicinal chemistry letters, 5(3), 1995, pp. 247-252
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
3
Year of publication
1995
Pages
247 - 252
Database
ISI
SICI code
0960-894X(1995)5:3<247:NWPDO2>2.0.ZU;2-N
Abstract
Three new phosphate derivatives of paclitaxel-2'-ethylcarbonate 4a, 4b , and 4c, have been synthesized and evaluated for in vivo antitumor ac tivity. All were soluble in water and two derivatives 4a and 4b were f ound to exhibit in vivo antitumor activity, comparable to paclitaxel i n the M109 murine tumor model.