INHIBITORS OF ACYL-COA-CHOLESTEROL O-ACYL TRANSFERASE (ACAT) AS HYPOCHOLESTEROLEMIC AGENTS .12. SYNTHESES AND BIOLOGICAL-ACTIVITY OF STRUCTURALLY NOVEL TETRAZOLE AMIDES

Authors
OBRIEN PM SLISKOVIC DR ANDERSON MK BOUSLEY RF KRAUSE BR STANFIELD RL
Citation
Pm. Obrien et al., INHIBITORS OF ACYL-COA-CHOLESTEROL O-ACYL TRANSFERASE (ACAT) AS HYPOCHOLESTEROLEMIC AGENTS .12. SYNTHESES AND BIOLOGICAL-ACTIVITY OF STRUCTURALLY NOVEL TETRAZOLE AMIDES, Bioorganic & medicinal chemistry letters, 5(3), 1995, pp. 289-294
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
3
Year of publication
1995
Pages
289 - 294
Database
ISI
SICI code
0960-894X(1995)5:3<289:IOAOT(>2.0.ZU;2-O
Abstract
The identification of tetrazole benzamide and nicotinamide derivatives as new structural classes of potent ACAT inhibitors is described. The ensuing structure-activity relationship (SAR) studies revealed that r etroamide 8c and 7q possesses comparable in vitro potency and efficacy to that of the fatty acid anilide, CI-976 (1).