DETERMINATION OF THE ENANTIOMER OF A CHOLESTEROL-LOWERING DRUG BY CYCLODEXTRIN-MODIFIED MICELLAR ELECTROKINETIC CHROMATOGRAPHY

Authors
NOROSKI JE MAYO DJ MORAN M
Citation
Je. Noroski et al., DETERMINATION OF THE ENANTIOMER OF A CHOLESTEROL-LOWERING DRUG BY CYCLODEXTRIN-MODIFIED MICELLAR ELECTROKINETIC CHROMATOGRAPHY, Journal of pharmaceutical and biomedical analysis, 13(1), 1995, pp. 45-52
Citations number
16
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Journal of pharmaceutical and biomedical analysis → ACNP
ISSN journal
07317085
Volume
13
Issue
1
Year of publication
1995
Pages
45 - 52
Database
ISI
SICI code
0731-7085(1995)13:1<45:DOTEOA>2.0.ZU;2-S
Abstract
The development, optimization and application of a chiral CE (capillar y electrophoresis) method for the determination of the enantiomer cont ent of a new cholesterol-lowering drug (EMS-180431-09) is discussed. T he chiral CE technique, cyclodextrin-modified micellar electrokinetic chromatography (CD-MEKC), was employed with hydroxypropyl beta-cyclode xtrin as the chiral selector in the run buffer. The detection limit of the unwanted enantiomer was about 0.06% w/w. The effect of various pa rameters on the separation, validation data and examples of the applic ation of the chiral CE method are included.