STRUCTURE-ACTIVITY-RELATIONSHIPS OF 4-SUBSTITUTED 1-ACYL AND 1,2-DIACYL-1,2,4-TRIAZOLIDINE-3,5-DIONES AS ANTIINFLAMMATORY AGENTS IN RODENTS

1-Acyl and 1,2-diacyl 1,2,4-triazolidine-3,5-diones proved to be poten t anti-inflammatory agents in rodents at 8 or 20 mg/kg. They were effe ctive against induced edema, pleurisy, and septic shock. Furthermore, these agents were potent in blocking the writhing reflex suggesting th at they should be effective against local pain generated by inflammato ry processes. These compounds were not lysosomal hydrolytic enzyme or proteolytic enzyme inhibitors in mouse liver, macrophages or human leu kocytes. However, the agents were potent inhibitors of prostaglandin a nd leukotriene de novo synthesis and have potential in acting as free radical scavengers.