ANTIINFLAMMATORY ACTIVITY OF AMINE-CARBOXYBORANES IN RODENTS

Amine-carboxyboranes are potent anti-inflammatory agents reducing indu ced edema and pleural effusion at 8 mg/Kg, i.p. They protect against L PS (Salmonella) induced septic shock from 2-8 mg/Kg/day and are effect ive in blocking pain mediated both locally and centrally. The mode of action of these agents is by blocking release of cytokines from macrop hages, thus reducing lysosomal hydrolytic and proteolytic enzyme activ ities of affected cells. The agents also reduce prostaglandin and leuk otriene synthesis by blocking the activities of regulatory enzymes of the respective pathways.