Amine-carboxyboranes are potent anti-inflammatory agents reducing indu
ced edema and pleural effusion at 8 mg/Kg, i.p. They protect against L
PS (Salmonella) induced septic shock from 2-8 mg/Kg/day and are effect
ive in blocking pain mediated both locally and centrally. The mode of
action of these agents is by blocking release of cytokines from macrop
hages, thus reducing lysosomal hydrolytic and proteolytic enzyme activ
ities of affected cells. The agents also reduce prostaglandin and leuk
otriene synthesis by blocking the activities of regulatory enzymes of
the respective pathways.