MASS BALANCING IN KINETIC RESOLUTION - CALCULATING YIELD AND ENANTIOMERIC EXCESS USING CHIRAL BALANCE

When kinetic resolution is applied for the production of enantiomerica lly pure compounds, process options may be used which involve more tha n one chiral substrate and one chiral product, such as sequential or p arallel enzymatic kinetic resolutions or hydrolysis of diastereomers. Although the relation between the yields (y) of the chiral compounds i s straightforward in these cases, the relation between their enantiome ric excess (ee) values is not. Combining mass balances into a so-calle d chiral balance (Sigma y.ee(R) = 0) provides the relation between ena ntiomeric excess values in a useful manner. This chiral balance easily shows which nonmeasured enantiomeric excess values and yields can be calculated from measured values. The chiral balance is only valid when configurations at chiral centers are conserved. (C) 1995 John Wiley a nd Sons, Inc.