Latex allergy caused by natural rubber latex proteins from Hevea brasi
liensis is recognized with increasing frequency due to the increased e
xposure to latex products in recent years. The allergens are not yet i
dentified or fully characterized. There are no dependable diagnostic m
ethods that can be safely used to determine latex allergy. This articl
e summarizes current knowledge about latex proteins and their allergen
icity. Suggestions are also made to direct future research, both for u
nderstanding latex allergic mechanisms and diagnosis of latex allergy.