CRYSTALLIZATION AND PRELIMINARY CRYSTALLOGRAPHIC ANALYSIS OF THE N-TERMINAL 2-DOMAIN FRAGMENT OF VASCULAR CELL-ADHESION MOLECULE-1 (VCAM-1)

A molecular fragment comprising the first two domains of the human vas cular cell adhesion molecule-1 (VCAM-1) has been crystallized by the v apor diffusion method, Two crystal forms have been examined by X-ray a nalysis: One crystal form belongs to the space group C2 with two molec ules in the asymmetric unit and cell parameters: a = 122.1 Angstrom, b = 48.9 Angstrom, c = 73.4 Angstrom, and beta = 117.4 degrees. The oth er crystal form belongs to the space group P2(1) with one molecule in the asymmetric unit and cell parameters: a = 40.4 Angstrom, b = 45.7 A ngstrom, c 54.7 Angstrom, and beta = 100.5 degrees. Diffraction data u p to 1.9 Angstrom resolution have been collected for the C2 crystal fo rm. (C) 1994 Wiley-Liss, Inc.