The genetic composition of a Yamana Indian group that still survives i
n Navarino Island, Port Williams, southern Chile, is described here. N
on-Indian admixture was estimated to be 12.9%. The Yamana are genetica
lly different from the Pehuenche Indians, especially for the HLA syste
m and the EsD locus. It is suggested that the Yamana have a more or le
ss direct Paleoindian origin. This hypothesis is supported by previous
archeological and bio-anthropological evidence. The presence of genes
from other Indian groups of Chile and Argentina in the gene pool of t
he Yamana, cannot be excluded on the basis of the present data.