ORTHOGONAL ARRAY DESIGN AS A CHEMOMETRIC METHOD FOR THE OPTIMIZATION OF ANALYTICAL PROCEDURES .4. MIXED-LEVEL DESIGN AND ITS APPLICATION TOTHE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION OF POLYCYCLIC AROMATIC-HYDROCARBONS

The theory and methodology of a mixed-level orthogonal array design fo r the optimization of analytical procedures is described. Firstly, the method of construction of a mixed-level orthogonal array design is di scussed in detail, followed by the assignment of experiments and the d ata analysis strategy in the design. The optimization of the parameter s involved in the high-performance liquid chromatographic determinatio n of polycyclic aromatic hydrocarbons is then employed to demonstrate the practical application of the proposed mixed-level orthogonal array design in the area of analytical chemistry.