HYPERESTROGENISM INDUCED BY MENOTROPINS ALONE OR IN CONJUNCTION WITH LUPROLIDE ACETATE IN IN-VITRO FERTILIZATION CYCLES - THE IMPACT ON HEMOSTASIS

Objective: To evaluate coagulation parameters during IVF cycles with e levated E2. Design: Prospective clinical study. Setting: Human Volunte ers in an IVF clinic. Patients: Infertile women undergoing IVF procedu res. Interventions: Coagulation factors were measured in blood along w ith E2 and P after singular hMG or leuprolide acetate (LA) plus hMG up to 14 days after hCG. Main Outcome Measures: Plasma coagulation facto rs. Results: Some coagulation factors were statistically but not clini cally elevated after LA-hMG-induced hyperestrogenism. For the most par t, this was not correlated with E2. Conclusion: This study suggests th at endogenous E2 increases due to fertility drugs cause ct molecular a ctivation of some coagulation factors, which do not result in an incre ased thrombosis.