INTRAVENOUS ENTEROSTATIN DOES NOT AFFECT SINGLE MEAL FOOD-INTAKE IN MAN

Enterostatin, a pentapeptide released with colipase from pancreatic pr ocolipase in man, affects eating behaviour in animals. We report the f irst phase II study of intravenous (i.v.) enterostatin (D3800) in obes e but otherwise healthy men. Eighteen men (mean age 37 years, mean bod y mass index 34.9 kg/m(2)) completed a double-blind, randomized, cross over placebo controlled trial. After an initial session, each man rece ived i.v. 4 mg D3800, 16 mg D3800 or placebo in random order over thre e sessions, immediately before a test meal served on a universal eatin g monitor. No statistically significant effect of i.v. enterostatin on any uptake or rating variable was observed. Several factors may expla in the lack of effect, e.g. the inability of i.v. enterostatin to reac h a site of action, the time between i.v. administration and eating, a nd the possibility that the only human responders are those who expres s particular fat preferences.