Diluted ProHance [Gd(HP-DO3A), Squibb Diagnostics, Princeton, NJ], Sus
tacal (Meadjohnson, Evansville, IN), a nutritional drink, and a ProHan
ce/Sustacal mixture have been investigated as potential oral contrast
agents. At 2 T, T-1-weighted (SE 500/20) images demonstrated hyperinte
nse (positive) signal enhancement of rat GI tracts within 10 min after
the ingestion of 2.0 mM Gd(HP-DO3A) or 2.0 mM ProHance/Sustacal. T-2-
weighted (SE 3000/80) images demonstrated hypointense (negative) signa
l intensity within 10 min after ingestion of 10 mM ProHance. Medical i
maging applications of these oral contrast media are feasible.