Diabetic muscle infarction (DMI) is a painful and potentially serious
complication in patients with poorly controlled diabetes mellitus. The
incidence of DMI is likely much greater than reports in the literatur
e suggest, perhaps secondary to the difficulty in making the diagnosis
and excluding other more serious etiologies. This paper describes the
role of MRI in the evaluation of a diabetic patient with a painful, s
wollen limb. Early application of MRI can more accurately classify the
disease process and focus the differential diagnosis, thus avoiding t
he hazards of medical therapy associated with other etiologies such as
deep venous thrombosis, cellulitis, or osteomyelitis. This paper desc
ribes the evaluation and diagnostic pitfalls encountered in two patien
ts. MRI techniques and applications are presented with a discussion of
clinical and radiological differential diagnoses.