Jb. Schmitz et al., THE UL37 PROTEIN OF HERPES-SIMPLEX VIRUS TYPE-1 IS ASSOCIATED WITH THE TEGUMENT OF PURIFIED VIRIONS, Virology, 206(2), 1995, pp. 1055-1065
The herpes simplex virus type 1 (HSV-1) UL37 open reading frame encode
s a 120-kDa late (gamma 1) phosphoprotein in infected cells. Analysis
of isolated mature HSV virions and light particles revealed that the U
L37 protein is a component of the virion. Detergent solubilization and
protease digestion experiments suggest that the UL37 protein is part
of the tegument structure. Indirect immunofluorescence experiments usi
ng HSV-1-infected cells and cells infected with a vaccinia recombinant
virus that expresses the UL37 gene demonstrated that the UL37 protein
is present in both the nucleus and cytoplasm of infected cells and th
at localization to the nucleus does not require additional HSV protein
s. (C) 1995 Academic Press, Inc.