EXPRESSION OF MULTIDRUG-RESISTANCE (MDR) GENE(S) IN PRIMARY LYMPHOID ORGANS OF CHICKEN IMMUNE-SYSTEM DURING EMBRYONIC-DEVELOPMENT

Authors
PETRINI M GALIMBERTI S SABBATINI A BIANCHI F BERNARDINI N DOLFI A LUPETTI M
Citation
M. Petrini et al., EXPRESSION OF MULTIDRUG-RESISTANCE (MDR) GENE(S) IN PRIMARY LYMPHOID ORGANS OF CHICKEN IMMUNE-SYSTEM DURING EMBRYONIC-DEVELOPMENT, Experientia, 51(2), 1995, pp. 137-140
Citations number
27
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Experientia → ACNP
ISSN journal
00144754
Volume
51
Issue
2
Year of publication
1995
Pages
137 - 140
Database
ISI
SICI code
0014-4754(1995)51:2<137:EOM(GI>2.0.ZU;2-B
Abstract
The presence of a multidrug resistance (MDR) related protein, P-170, i n normal and pathological lymphoid cells has been described. The prese nt report evaluates the expression of the mdr 1 gene by using the reve rse Polymerase Chain Reaction (PCR) on cells obtained from the thymus and bursa of chicken embryos starting from day 12 until hatching. Resu lts show that the thymic cells are positive from day 12 to the end of the observation period. In contrast, mdr mRNA was detected in the burs a from day 14 to day 17 of embryonic life. Possible relationships betw een the expression of mdr and the development of T and B lymphocytes a re discussed.