F. Dhermies et al., MIRAGEL VERSUS SILASTIC USED AS EPISCLERAL IMPLANTS IN RABBITS - AN EXPERIMENTAL AND HISTOPATHOLOGIC COMPARATIVE-STUDY, Retina, 15(1), 1995, pp. 62-67
Purpose: Tissue reactions to two different biomaterials implanted on t
he sclera of rabbit eyes, a silicone implant (Silastic;.Dow Coming) an
d a hydrogel (Miragel; Mira Inc.), were evaluated. Methods: Both mater
ials were implanted on the scleral surface under the superior rectus t
o obtain a focal scleral buckling. Histopathologic examination of the
32 eyes was performed with transmission electron microscopy 5 to 8 mon
ths after implantation. Results: During the follow-up period, 6 silico
ne implants were extruded, compared with only one hydrogel implant. Hi
stopathologically, both types of implants were surrounded by a newly f
ormed fibrous capsule. Only the hydrogel implant gave rise to a granul
omatous foreign body reaction against its own fragments, however. Conc
lusion: The main difference between the two types of material was a su
perficial fragmentation of the hydrogel implants. The reason for this
fragmentation is unknown, To our knowledge, this is the first reported
case of foreign body giant cell granuloma that developed against a hy
drogel implant.