H-1-NMR CHIRAL ANALYSIS OF BENZHYDRYLAMINE DERIVATIVES USING BETA-CYCLODEXTRIN - SOLUTION GEOMETRY OF HOST-GUEST COMPLEXES AS DETERMINED BY1D NOE AND ROESY EXPERIMENTS

The H-1 NMR chiral analysis of a series of benzhydrylamine derivatives was accomplished by means of beta-cyclodextrin as chiral resolving ag ent, forming the corresponding inclusion complexes in aqueous solution . NOE and ROESY experiments were used in order to establish the most p robable host-guest geometries in solution. In all cases studied, it wa s found that the phenyl groups of guest molecules preferably binds wit h the macrocyclic cavity of beta-cyclodextrin, thus forming ternary co mplexes (2:1, beta-cyclodextrin:guest) when two phenyl groups were pre sent in the guest molecule.