K. Husgafvelpursiainen et al., P53 AND RAS GENE-MUTATIONS IN LUNG-CANCER - IMPLICATIONS FOR SMOKING AND OCCUPATIONAL EXPOSURES, Journal of occupational and environmental medicine, 37(1), 1995, pp. 69-76
This paper reviews mutational activation of ras oncogenes and inactiva
tion of the p53 tumor suppressor gene in human lung cancer. We discuss
the frequency, type, and location of mutations in these genes in rela
tion to Known etiological factors for lung cancer. The most studied ex
amples of these are exposure to tobacco smoke, and to radon and asbest
os fibers at work. We summarize data from our laboratory on K-ras and
p53 mutations in fresh tissue samples from patients with resected prim
ary lung carcinoma whose smoking and occupational histories were Known
. Most of the tumors examined were histologically non-small cell carci
noma (NSCLC), mainly of the squamous cell carcinoma and adenocarcinoma
types. We compare the prevalence and nature of mutations in the two h
istological types of NSCLC.