THE MOLECULAR EPIDEMIOLOGY OF GROWTH SIGNAL-TRANSDUCTION PROTEINS

Citation
Pw. Brandtrauf et al., THE MOLECULAR EPIDEMIOLOGY OF GROWTH SIGNAL-TRANSDUCTION PROTEINS, Journal of occupational and environmental medicine, 37(1), 1995, pp. 77-83
Citations number
44
Categorie Soggetti
Public, Environmental & Occupation Heath
ISSN journal
10762752
Volume
37
Issue
1
Year of publication
1995
Pages
77 - 83
Database
ISI
SICI code
1076-2752(1995)37:1<77:TMEOGS>2.0.ZU;2-Q
Abstract
Cellular proteins involved in growth signal transduction pathways repr esent potential molecular epidemiologic biomarkers for various disease processes of toxicologic interest, particularly cancer. In many insta nces, the proteins gain access to the extracellular environment and th us can be detected in easily accessible biological fluids such as seru m or plasma. This paper reviews the experience with selected examples of such proteins, including growth factors, growth factor receptors, G proteins, and nuclear DNA-binding proteins, as serum or plasma biomar kers of disease.