Pw. Brandtrauf et al., THE MOLECULAR EPIDEMIOLOGY OF GROWTH SIGNAL-TRANSDUCTION PROTEINS, Journal of occupational and environmental medicine, 37(1), 1995, pp. 77-83
Cellular proteins involved in growth signal transduction pathways repr
esent potential molecular epidemiologic biomarkers for various disease
processes of toxicologic interest, particularly cancer. In many insta
nces, the proteins gain access to the extracellular environment and th
us can be detected in easily accessible biological fluids such as seru
m or plasma. This paper reviews the experience with selected examples
of such proteins, including growth factors, growth factor receptors, G
proteins, and nuclear DNA-binding proteins, as serum or plasma biomar
kers of disease.