ATP-MGCL2, ADDED TO RESUSCITATION IMPROVES SURVIVAL IN AN EXPERIMENTAL-MODEL OF HEMORRHAGIC-SHOCK

The administration of ATP-MgCl2 may be of benefit in the treatment of shock by improving cellular metabolic function during resuscitation. P rior studies have reported data from hemorrhage models in which hepari nized shed blood is returned both during shock and in resuscitation. T he purpose of this study was to test the effects of ATP-MgCl2 therapy upon blood pressure and survival in an animal model of hemorrhagic sho ck utilizing crystalloid (Lactated Ringer's) resuscitation. Adult male Sprague-Dawley rats (340-360 g) were bled 27 cc/kg and maintained in shock for 45 min. At the end of the shock period, animals were resusci tated with crystalloid at twice the original hemorrhage volume. A blin ded three-arm study was conducted and animals were assigned to receive either Lactated Ringer's (LR) with placebo, LR with MgCl2, or LR with ATP-MgCl2. Blood pressure was monitored throughout the procedure and survival time was noted. Post-resuscitation MAP was increased in anima ls treated with ATP-MgCl2. ATP-MgCl2 added to resuscitation significan tly improved 72-h survival over that of control (LR) animals, and anim als treated with MgCl2 alone.