STRUCTURAL AND STEREOCHEMICAL REQUIREMENTS OF TIME-DEPENDENT INACTIVATORS OF THE INTERLEUKIN-1-BETA CONVERTING-ENZYME

Authors
PRASAD CVC PROUTY CP HOYER D ROSS TM SALVINO JM AWAD M GRAYBILL TL SCHMIDT SJ OSIFO IK DOLLE RE HELASZEK CT MILLER RE ATOR MA
Citation
Cvc. Prasad et al., STRUCTURAL AND STEREOCHEMICAL REQUIREMENTS OF TIME-DEPENDENT INACTIVATORS OF THE INTERLEUKIN-1-BETA CONVERTING-ENZYME, Bioorganic & medicinal chemistry letters, 5(4), 1995, pp. 315-318
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
4
Year of publication
1995
Pages
315 - 318
Database
ISI
SICI code
0960-894X(1995)5:4<315:SASROT>2.0.ZU;2-4
Abstract
Structural and stereochemical requirements of substrate based time-dep endent inactivators of interleukin-1 beta converting enzyme were inves tigated. Hydrophobic amino acids with L-stereochemistry are preferred at the P-2 and P-3 positions. It appears that both D- and L-Asp are ac cepted by the enzyme at the P-1 position.