STRUCTURE-ACTIVITY-RELATIONSHIPS OF NONPEPTIDE BRADYKININ B-2 RECEPTOR ANTAGONISTS

Authors
SALVINO JM SEOANE PR DOUTY BD AWAD MA HOYER D ROSS TM DOLLE RE HOUCK WT FAUNCE DM SAWUTZ DG
Citation
Jm. Salvino et al., STRUCTURE-ACTIVITY-RELATIONSHIPS OF NONPEPTIDE BRADYKININ B-2 RECEPTOR ANTAGONISTS, Bioorganic & medicinal chemistry letters, 5(4), 1995, pp. 357-362
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
4
Year of publication
1995
Pages
357 - 362
Database
ISI
SICI code
0960-894X(1995)5:4<357:SONBBR>2.0.ZU;2-K
Abstract
A series of non-peptide competitive antagonists of the human IMR 90 fe tal lung fibroblast bradykinin B-2 receptor have been designed and syn thesized. Compound 15 binds with an affinity constant K-i = 60 nM. The SAR leading to the design of these non-peptide antagonists is describ ed.