POTENT MAMMALIAN TOPOISOMERASE-II INHIBITORS - 2,6-DIMETHYL-4-PYRIDINYL)-4-SUBSTITUTED-QUINOLINES

Authors
KUO GH EISSENSTAT MA WENTLAND MP ROBINSON RG KLINGBEIL KM DANZ DW COUGHLIN SA
Citation
Gh. Kuo et al., POTENT MAMMALIAN TOPOISOMERASE-II INHIBITORS - 2,6-DIMETHYL-4-PYRIDINYL)-4-SUBSTITUTED-QUINOLINES, Bioorganic & medicinal chemistry letters, 5(4), 1995, pp. 399-404
Citations number
26
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
4
Year of publication
1995
Pages
399 - 404
Database
ISI
SICI code
0960-894X(1995)5:4<399:PMTI-2>2.0.ZU;2-1
Abstract
A series of novel 4-substituted-1,4-dihydro-quinolines 3 were prepared and found to exhibit moderate to excellent mammalian topo II inhibito ry activity. Among the compounds prepared, in general, the nitrogen an alogues are the most active compounds and the sulfur analogue is the l east active one.